Covid
Parham Maroufi; Tala Pourlak
Abstract
Introduction: Determining pre-operative platelet levels and their potential correlation with intraoperative bleeding is an important area of investigation in tibia fracture surgery. Platelet parameters, including platelet count, MPV, PDW, and PCT, have shown promise as potential predictors of bleeding ...
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Introduction: Determining pre-operative platelet levels and their potential correlation with intraoperative bleeding is an important area of investigation in tibia fracture surgery. Platelet parameters, including platelet count, MPV, PDW, and PCT, have shown promise as potential predictors of bleeding tendencies during surgery. By considering these parameters and other relevant clinical factors, healthcare professionals can enhance surgical planning, optimize patient care, and improve outcomes in tibia fracture surgery.Material and Methods: Pre-operative platelet levels were determined by collecting a venous blood sample from each participant within 24 hours before surgery. The blood samples were collected using standard aseptic techniques and transferred to the hospital laboratory for analysis. Platelet counts were measured using an automated hematology analyzer, which provided accurate and reliable results. During tibia fracture surgery, the amount of bleeding was measured and recorded. The surgical team employed standard techniques for intraoperative blood loss measurement, including the use of suction devices and weighing surgical sponges.Results: The results revealed a significant positive correlation between platelet count and intraoperative bleeding (p < 0.05), indicating that higher platelet counts were associated with increased amounts of bleeding during tibia fracture surgery. However, no significant correlations were observed between MPV, PDW, PCT, and intraoperative bleeding (p > 0.05).Conclusion: this study provides evidence of a significant positive correlation between pre-operative platelet count and the amount of bleeding during tibia fracture surgery. Higher platelet counts were associated with increased amounts of bleeding, suggesting that platelet count may serve as a valuable predictor of bleeding tendencies in this surgical population.
Medicine
Parham Maroufi; Tala Pourlak
Abstract
Introduction: this study aims to investigate the levels of ficolin-2 in patients with OA and explore its relationship with age. By elucidating the potential role of ficolin-2 in OA pathophysiology and its association with age-related changes, this study may contribute to our understanding of the inflammatory ...
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Introduction: this study aims to investigate the levels of ficolin-2 in patients with OA and explore its relationship with age. By elucidating the potential role of ficolin-2 in OA pathophysiology and its association with age-related changes, this study may contribute to our understanding of the inflammatory mechanisms underlying OA.Material and Methods: Ficolin-2 levels were quantified using a dedicated human ficolin-2 enzyme-linked immunosorbent assay (ELISA) kit. The assay followed the manufacturer's instructions with duplicate measurements for each sample. Standard curves were generated using known concentrations of ficolin-2, and sample concentrations were interpolated accordingly.Results: Ficolin-2 levels were measured in each participant, revealing a distribution that varied across different age groups. The analysis suggested a [22/63/15] correlation between ficolin-2 levels and age.Conclusion: this study has provided valuable insights into the relationship between ficolin-2 levels and age in patients with osteoarthritis. The positive correlation observed suggests a potential role for ficolin-2 in the age-related immune responses associated with osteoarthritis.
Medicine
Parisa Mehrasa; Tala Pourlak
Abstract
Introduction: This is because the development of cytokine release syndrome (CRS) as the pathologic basis for the progression of severe Covid-19 disease is possible. Material and Methods: A two-step selection process that involved first screening studies based on their titles and abstracts and then reading ...
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Introduction: This is because the development of cytokine release syndrome (CRS) as the pathologic basis for the progression of severe Covid-19 disease is possible. Material and Methods: A two-step selection process that involved first screening studies based on their titles and abstracts and then reading the full texts of those studies was carried out independently by the two reviewers. Studies were considered if they were RCTs, observational cohorts, or case-control in design, described two or more patients diagnosed with Covid19, and reported measures of cytokine levels (with a focus on IL-6). The use of standardized data extraction tables allowed for the duplication of the data extraction process. Data were taken from the text of the article, the tables, and the graphs.Results: In all of the studies that were included, elevated IL-6 levels were found in Covid-19 patients. Numerous studies specifically found that patients with more severe (complicated) diseases had higher levels of IL-6 descriptions of other inflammatory markers, such as ferritin and IL2R. Six studies in total compared the levels of IL-6 in patients with complicated disease (those with ARDS, needing ICU admission, or having "severe" or "critical" presentations according to the Chinese New Coronavirus Pneumonia Prevention and Control Program score) and noncomplicated disease (those without the aforementioned criteria present).Conclusion: In this systematic review and meta-analysis, we show that elevated serum IL-6 levels are associated with complicated Covid 19 disease and that these elevated IL-6 levels are also significantly associated with poor clinical outcomes. This implies that an excessive host immune response and autoimmune injury may be the result of an initial SARS-CoV2 infection that progresses to a complicated disease. These results underline the necessity of continuing, carefully designed clinical studies to clarify the function of immunomodulation, specifically IL-6 inhibition, in the treatment of severe Covid-19.
